2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W031727S1
    Hydroxychloroquine-d5
    Hydroxychloroquine-d5 is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].
    Hydroxychloroquine-d<sub>5</sub>
  • HY-N10899
    Bruceine J
    		Inhibitor
    Bruceine J, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine J has anti-Babesial activity.
    Bruceine J
  • HY-N10197
    Pulixin
    		Inhibitor
    Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC50 of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC50 of 47 nM.
    Pulixin
  • HY-B0806S1
    Proguanil-d4
    Proguanil-d4 is the deuterium labeled Proguanil[1]. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor[2][3].
    Proguanil-d<sub>4</sub>
  • HY-N9179
    3′,4′,5′,5,6,7-Hexamethoxyflavone
    		Inhibitor
    3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC50 of 21.3 μM (8.58 g/mL).
    3′,4′,5′,5,6,7-Hexamethoxyflavone
  • HY-133004
    Fenbutatin oxide
    		Inhibitor
    Fenbutatin oxide is an organotin acaricide.
    Fenbutatin oxide
  • HY-N9194
    5-Methoxycanthin-6-one
    5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC50 of 5.44 μg/mL against Ailanthus altissima cells.
    5-Methoxycanthin-6-one
  • HY-126812
    Longestin
    		Inhibitor
    Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent.
    Longestin
  • HY-163997
    Antimalarial agent 42
    		Inhibitor
    Antimalarial agent 42 (Compound 2) is an antimalarial agent, that inhibits Plasmodium falciparum in the phase of asexual blood stages (IC50 <0.5μM) and gametocytes (IC50 is 0.14 μM).
    Antimalarial agent 42
  • HY-109077S
    Tigolaner-d4
    Tigolaner-d4 is deuterium labeled Tigolaner. Tigolaner is a GABA antagonist that regulates chloride channel. Tigolaner is an antiparasitic agent[1].
    Tigolaner-d<sub>4</sub>
  • HY-136450S1
    Triclabendazole sulfoxide-13C,d3
    		Inhibitor
    Triclabendazole sulfoxide-13C,d3 is the 13C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
    Triclabendazole sulfoxide-<sup>13</sup>C,d<sub>3</sub>
  • HY-B0817S
    Pyridaben-d13
    Pyridaben-d13 is the deuterium labeled Pyridaben[1]. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[2][3].
    Pyridaben-d<sub>13</sub>
  • HY-N9438R
    Lactucin (Standard)
    		Inhibitor
    Lactucin (Standard) is the analytical standard of Lactucin. This product is intended for research and analytical applications. Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[4].
    Lactucin (Standard)
  • HY-B0827S
    Dinotefuran-d3
    Dinotefuran-d3 is the deuterium labeled Dinotefuran[1]. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors[2].
    Dinotefuran-d<sub>3</sub>
  • HY-145431
    (S)-GSK1379725A
    		Inhibitor
    (S)-GSK1379725A (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. (S)-GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S)-GSK1379725A shows antimalarial activity.
    (S)-GSK1379725A
  • HY-163890
    Succinate dehydrogenase-IN-2
    		Inhibitor
    Succinate dehydrogenase-IN-2 (Compound 12x) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 1.22 mg/L. Succinate dehydrogenase-IN-2 exhibits antifungal activity, that inhibits S. sclerotiorum, V. mali, G. graminis, R. solani and B. cinerea with EC50 of 0.52-3.42 mg/L.
    Succinate dehydrogenase-IN-2
  • HY-122517
    Mirincamycin hydrochloride
    		Inhibitor
    Mirincamycin (hydrochloride) (U-24729 A), a compound used to inhibit malaria, has a protective effect against the early liver stages of Plasmodium but fails to kill dormant liver stages of Plasmodium in a rhesus monkey model.
    Mirincamycin hydrochloride
  • HY-B1282S
    Sulfaquinoxaline-d4
    		Inhibitor
    Sulfaquinoxaline-d4 is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].
    Sulfaquinoxaline-d<sub>4</sub>
  • HY-116511
    Benzoximate
    		Inhibitor
    Benzoximate is an acaricide that inhibits fruit tree red spider mite Panonychys ulmi (Koch).
    Benzoximate
  • HY-136448
    SJ000025081
    		Inhibitor
    SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii.
    SJ000025081
Parasite Isoform Comparison

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